Papain S500/6500L (food grade)

An Enzyme Supplies Papain enzyme for the protein & dietetics industries


Papain 6500L is a purified proteolytic enzyme preparation that is obtained from the fruit ‘Papaya carica’. Papain 6500L is an endo-peptidase that degrades high molecular proteins into low molecular peptides and amino acids.
• IUB-No.:
• CAS-No.: 9001-73-4

Typical Characteristics

Papain 6500L has the following characteristics: a) liquid product
b) light yellow colour with characteristic smell c) specific weight: 1.2 g/ml pH and temperature optimum:
pH optimum 6.0-8.0 (range 5.0-9.0) Temperature optimum 60-70oC (range 45-75oC)


Papain 6500L is available in 25-kg PE cans.


Papain 6500L can be stored at cool and dry conditions (6 – 10°C) in original packaging for 12 months.


Papain 6500L is standardized in NFPU/ml (according to the FCC method) A description of the analysis method is available on request.


Avoid the formation of aerosol and dust of the product. Repeated inhalation of enzyme aerosol or dust may cause sensitisation and may cause allergic type reactions in sensitised individuals. Proteases are irritating to eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. For detailed information please refer to the Material Safety Data Sheet (MSDS).

Application Scope

Papain 6500L hydrolyses all kind of proteins. Potential applications are: • chill proofing of beer
• degradation of fish protein
• meat tenderizing, marinades • peptone production

Dose Recommendation

The dosage depends on the reaction conditions such as substrate, pH, temperature and the required degree of hydrolysis. Typical dosages are:
• chill proofing of beer: 1 – 3 ml / hl beer
• degradation of fish protein: 200 – 300 g / t of fish by-products • meat tenderizing: 20 – 30 g / 100 kg meat.
• pepton production: 0.5 – 5 g / kg based on protein content

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We have greatly benefitted from working with Enzyme Supplies, and we recommend their thoroughly professional service to anyone seeking technical expertise and a reliable, reputable source of industrial enzyme products.”

We have been supplied by Enzyme Supplies for over 3 years and have found their material and service very satisfactory. On one occasion they helped to supply at very short notice when another supplier let us down which could have resulted in very serious disruption.

have been working with Enzyme Supplies over the last twelve months and am extremely grateful for their expert advice, consistent and reliable service and most importantly, the ability to meet the continuing demands of my business, particularly in the area of API sourcing.  They continue to assist me with this key function and are willing to provide additional services when needed which may arise from time to time. I highly recommend using Enzyme Supplies to future customers and appreciate their ongoing support for our business

Enzyme Supplies’ has been supplying us with a range of enzymes for over 3 years…consistently high quality…competitive… efficient…will continue to use Enzyme Supplies as it’s supplier of enzyme

We changed from one of your competitors and now purchase our enzymes from Enzyme Supplies. The improvement in lead time has been fantastic and your service is excellent. Any question has been answered promptly and with a deep understanding of the material you provide, this did not happen with our previous supplier. I have already told you that I intend our relationship will be a long term one’.

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